Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies.
However, fluctuations in weight due to age-related hormonal changes and changes in lifestyle practices may bias relative risk estimates over a long follow-up period.
The authors prospectively studied the association between body mass index (BMI) (kg/m2), waist-to-hip ratio, and height as independent predictors of incident coronary heart disease in a 3-year prospective study among 29,122 US men aged 40-75 years in 1986.
The authors documented 420 incident coronary events during the follow-up period.
Among men younger than 65, after adjusting for other coronary risk factors, the relative risk was 1.72 (95% confidence interval (Cl) 1.102.69) for men with BMI of 25-28.9,2.61 (95% Cl 1.54-4.42) for BMI of 29.0-32.9, and 3.44 (95% Cl 1.67-7.09) for obese men with BMI =33 compared with lean men with BMI<23.0. Among men<65 years of age, the association between BMI and risk of coronary heart disease was much weaker.
However, in this age group, the waist-to-hip ratio was a much stronger predictor of risk.
These results suggest that for younger men, obesity, independent of fat distribution, is a strong risk factor for coronary heart disease.
For older men, measures of fat distribution may be better than body mass index at predicting risk of coronary disease.
An J Epidemiol 1995 ; 141 : 1117-27.
Mots-clés Pascal : Cardiopathie coronaire, Epidémiologie, Vieillard, Homme, Mâle, Tissu adipeux, Obésité, Indice masse corporelle, Biométrie corporelle, Facteur risque, Etude longitudinale, Etats Unis, Amérique du Nord, Amérique, Prospective, Etat nutritionnel, Appareil circulatoire pathologie, Trouble nutrition
Mots-clés Pascal anglais : Coronary heart disease, Epidemiology, Elderly, Human, Male, Adipose tissue, Obesity, Body mass index, Corporal biometry, Risk factor, Follow up study, United States, North America, America, Prospective, Nutritional status, Cardiovascular disease, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0378994
Code Inist : 002B12A03. Création : 01/03/1996.