The frequency of hepatitis B surface antigen (HBsAg) was studied in the sera of 622 patients with glomerulonephritis (GN).
The prevalence of HBs-antigenemia was 2.8% (18/622 ; eleven adults and seven children) ; the difference from 2.6% in the general population of Central and Southern Greece was not statistically significant (X2=0.01 ; p>0.50).
Two of the 11 HBsAg-seropositive adult patients with GN suffered from IgA nephropathy, one from IgA and membranous glomerulonephritis (MGN), four from diffuse proliferative GN, two from membranous GN and one each from crescentic GN and focal segmental glomerulosclerosis.
Five children out of 12 with membranous glomerulonephritis, one out of 24 with IgA nephropathy and one out of 16 with focal segmental glomerulosclerosis had HBs-antigenemia.
The frequency of HBs-antigenemia in children with MGN was 41.7%, which is significantly higher than in children with others types of GN (0.9%). All seropositive patients were asymptomatic HBsAg carriers, while one seropositive HBsAg child with MGN suffered from chronic persistent hepatitis.
Our study suggests that in the Greek population there is no increased prevalence of HBs-antigenemia in patients with glomerulonephritis.
Moreover, HBsAg was not found to contribute in the pathogenesis of GN in adults but it may be associated with the pathogenesis of membranous GN in children.
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Néphropathie glomérulaire, Sérologie, Prévalence, Epidémiologie, Enfant, Homme, Adulte, Association, Grèce, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Glomerulonephritis, Serology, Prevalence, Epidemiology, Child, Human, Adult, Association, Greece, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0362439
Code Inist : 002B05C02G. Création : 01/03/1996.