In order to assess the interaction between alcohol intake, tobacco smoking and coffee consumption in determining the risk of liver cirrhosis we carried out a hospital-based case-control study involving 115 patients at their first diagnosis of cirrhosis and 167 control patients consecutively enrolled in the General Hospitals of the Province of L'Aquila (Central Italy).
The mean life-time daily alcohol intake (as g ethanol consumed daily) was measured by direct patient interviews, whose reproducibility was>0.80 and similar for cases and controls, as checked by interviewing the relatives of a sample of 50 cases and 73 controls.
During the same patient's interview we also measured the mean consumption of coffee (daily number of cups of filtered coffee) and tobacco (life-time daily number of cigarettes smoked).
A dose-effect relationship on the risk of cirrhosis was present both for alcohol intake - for which the risk was significantly increased above 100 g of daily intake - and for cigarette consumption.
The latter did not however improve the goodness-of-fit of a logistic regression model including alcohol intake as covariate.
We conclude that : (1) tobacco smoking is likely to be a faint risk factor for cirrhosis, and studies on wider patients series should be performed for confirmation ; (2) coffee drinking is associated with a reduced risk of cirrhosis.
Mots-clés Pascal : Cirrhose, Foie, Consommation, Ethanol, Tabagisme, Café, Boisson stimulante, Interaction toxique, Epidémiologie, Milieu hospitalier, Italie, Europe, Homme, Appareil digestif pathologie, Foie pathologie, Etude cas témoin
Mots-clés Pascal anglais : Cirrhosis, Liver, Consumption, Ethanol, Tobacco smoking, Coffee, Stimulative beverage, Poison interaction, Epidemiology, Hospital environment, Italy, Europe, Human, Digestive diseases, Hepatic disease, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0362412
Code Inist : 002B03F. Création : 01/03/1996.