In August, 1993,13 dialysis patients at one dialysis centre in Colombia, South America, were found to be HIV positive, and this prompted an epidemiological investigation.
We carried out a cohort study of all dialysis centre patients during January, 1892 to December, 1993 (epidemic period) to determine risk factors for HIV seroconversion, Haemodialysis and medical records were reviewed, dialysis centre staff and surviving patients were interviewed, and dialysis practices were observed.
Stored sera from all dialysis centre patients were tested for HIV antibody. 12 (52%) of 23 patients tested positive for HIV antibody by enzyme immunoassay and western blot during the epidemic period.
Of the 23 tested, 9 (39%) converted from HIV antibody negative to positive (seroconverters) and 10 (44%) remained HIV negative (seronegatives).
The HIV seroconversion rate was higher among patients dialysed at the centre while a new patient, who was HIV seropositive, was dialysed there (90% vs 0% ; p<0.01), or when the dialysis centre reprocessed access needles, dialysers, and bloodlines (60% vs 0%). While 2 of 9 HIV seroconverters had had sex with prostitutes, none had received unscreened blood products or had other HIV risk factors.
No surgical or dental procedures were associated with HIV seroconversion.
Mots-clés Pascal : SIDA, Virose, Infection, Immunopathologie, Immunodéficit, Mode transmission, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Association, Dialyse, Facteur risque, Epidémiologie, Colombie, Amérique du Sud, Amérique
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Immunopathology, Immune deficiency, Transmission mode, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Association, Dialysis, Risk factor, Epidemiology, Colombia, South America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0357808
Code Inist : 002B06D01. Création : 01/03/1996.