Multiple false reactions in viral antibody screening assays after influenza vaccination.
In December 1991, US blood centers reported an unusual increase in donations that tested falsely reactive for antibodies to two or more (multiple false positive) of the following viruses : human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotrophic virus type I (HTLV-I), and hepatitis C virus.
Many of these donations were from people who had recently received the 1991-1992 influenza vaccine, raising the possibility that this vaccine had somehow specifically caused the problem of multiple false reactivity.
A case-control study of 101 affected donors and 191 matched controls found that recent receipt of any brand of influenza vaccine was significantly associated with testing multiple false positive (p<0.05), as was a history of recent acute illness (p<0.05) and of allergies (p<0.05).
Surveillance for monthly rates of multiple reactive donations from May 1990 through December 1992 linked the seasonal cluster of multiple false-positive donations to the use of viral screening test kits thought to react nonspecifically to donor immunoglobulin M. There was no similar increase in multiple false-positive donations during the 1992-1993 influenza vaccination season after the HIV-1 and hepatitis C virus tests were replaced ; however, the number of donations that were falsely reactive for only HTLV-I almost doubled, indicating that false reactivity was not specifically associated with the 1991-1992 influenza vaccine.
Mots-clés Pascal : Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Virus HTLV1, Virus hépatite C, Flaviviridae, Méthode étude, Dépistage, Faux positif, Epidémiologie, Donneur sang, Homme, Vaccination, Grippe, Virose, Infection, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, HTLV-I virus, Hepatitis C virus, Flaviviridae, Investigation method, Medical screening, False positive, Epidemiology, Blood donor, Human, Vaccination, Influenza, Viral disease, Infection, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0354895
Code Inist : 002A05C09. Création : 01/03/1996.