Human leukocyte antigen (HLA) molecules, whose biological role is in the regulation of immune responses to foreign antigens and in discrimination of self from non-self antigens, are encoded by a series of closely linked genetic loci found on chromosome 6. Since HLA associations between human papillomavirus type 16 (HPV16) - mediated cancer cases and non-HPV16-mediated cancer cases have been found to be different, this suggests that specific HLA class II haplotypes may influence the immune response to HPV infection and may affect the risk of acquiring invasive cervical carcinoma.
This study was conducted to determine if the same HLA class II haplotypes that are associated with invasive cervical carcinoma are also associated with cervical dysplasia (presumed precursors of invasive cervical cancer).
We have examined HLA DR-DQ haplotypes among 128 Hispanic women from New Mexico with biopsy-confirmed cervical dysplasia in a case-control study using sensitive DNA-based polymerase chain reaction amplification and sequence-specific oligonucleotide probe hybridization methods to detect the presence and type of HPV and to detect allelic polymorphism in the HLA DRB1 and DQB1 loci.
Mots-clés Pascal : Epithélioma, Col utérus, Etude comparative, Dysplasie, Antigène histocompatibilité classe II, Système HLA, Système histocompatibilité majeur, Haplotype, Epidémiologie, Latinoaméricain, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Col utérus pathologie, Appareil génital femelle pathologie, Lésion précancéreuse
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Comparative study, Dysplasia, Class II histocompatibility antigen, HLA-System, Major histocompatibility system, Haplotype, Epidemiology, Latinamerican, United States, North America, America, Human, Malignant tumor, Uterine cervix diseases, Female genital diseases, Premalignant lesion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0352552
Code Inist : 002B20C02. Création : 01/03/1996.