The increasing incidence of prostate cancer creates complex issues in health care management and cost containment.
There is a need to evaluate serial measurements of prostate-specific antigen (PSA) as a marker for long-term risk of clinically important prostate cancer (stages B through D).
We used a nested case-control design within a retrospective cohort study to evaluate serial PSA concentrations in relation to subsequent prostate cancer diagnoses.
Median serum PSA concentrations, specific for age and subsequent cancer status, were similar in blacks and whites.
Concentrations in control subjects increased exponentially with age, with a doubling time of 24.9 years.
Concentrations in men with stage A cancer were similar to those in control subjects.
Until about 13 years before diagnosis, PSA in men with subsequent cancer stages B through D increased exponentially with age, with a doubling time similar to that of control subjects.
These data suggest that 1) age-specific PSA concentrations are similar in black men and white men and 2) current PSA concentration, specific for age, outperforms changes in past concentrations in identifying the man who will develop stage B, C, or D cancer within 7 years, albeit at the cost of a slightly higher rate of false-positive results.
This interpretation needs confirmation in other data containing many serial PSA measurements within a few years of diagnosis.
Mots-clés Pascal : Tumeur maligne, Prostate, Marqueur tumoral, Facteur risque, Epidémiologie, Caucasoïde, Négroïde, Etats Unis, Amérique du Nord, Amérique, Homme, Prostate pathologie, Appareil urinaire pathologie, Appareil génital mâle pathologie, Antigène spécifique prostate
Mots-clés Pascal anglais : Malignant tumor, Prostate, Tumoral marker, Risk factor, Epidemiology, Caucasoid, Negroid, United States, North America, America, Human, Prostate disease, Urinary system disease, Male genital diseases, Prostate specific antigen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0352382
Code Inist : 002B14D02. Création : 01/03/1996.