Prospective study of toenail selenium levels and cancer among women.
Inverse associations between selenium status and cancer risk have been observed in animal studies, ecologic studies, and some case-control and prospective studies.
Whereas results of some prospective studies have suggested an overall inverse relationship between selenium levels and cancer, other prospective studies have failed to confirm this finding.
Prospective data on women are particularly limited because fewer women than men have been studied prospectively.
The aim of this study was to prospectively examine the relationship between selenium levels in toenails (previously shown to reflect selenium intake) and incidence of cancer among women.
The Nurses'Health Study cohort began in 1976 with 121 700 female nurses aged 30-55 years living in 11 U.S. states.
In 1982, we requested toenail clippings from the members of the cohort, and 62 641 participants with no history of cancer returned these clippings.
During 41 months of follow-up, 503 cases of cancer other than breast cancer (results previously reported) or nonmelanoma skin cancer were analyzed.
For each case patient, a control subject was chosen from women who remained free of diagnosed cancer, matched by age and by date of nail return.
Toenail selenium levels were not inversely associated with cancer risk in this study.
Mots-clés Pascal : Tumeur maligne, Facteur risque, Epidémiologie, Sélénium, Orteil, Ongle, Etats Unis, Amérique du Nord, Amérique, Femelle, Homme
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Epidemiology, Selenium, Toe, Nail(anatomy), United States, North America, America, Female, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0351968
Code Inist : 002B04B. Création : 01/03/1996.