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  1. Prospective study of toenail selenium levels and cancer among women.

    Article - En anglais

    Background 

    Inverse associations between selenium status and cancer risk have been observed in animal studies, ecologic studies, and some case-control and prospective studies.

    Whereas results of some prospective studies have suggested an overall inverse relationship between selenium levels and cancer, other prospective studies have failed to confirm this finding.

    Prospective data on women are particularly limited because fewer women than men have been studied prospectively.

    Purpose 

    The aim of this study was to prospectively examine the relationship between selenium levels in toenails (previously shown to reflect selenium intake) and incidence of cancer among women.

    Methods 

    The Nurses'Health Study cohort began in 1976 with 121 700 female nurses aged 30-55 years living in 11 U.S. states.

    In 1982, we requested toenail clippings from the members of the cohort, and 62 641 participants with no history of cancer returned these clippings.

    During 41 months of follow-up, 503 cases of cancer other than breast cancer (results previously reported) or nonmelanoma skin cancer were analyzed.

    For each case patient, a control subject was chosen from women who remained free of diagnosed cancer, matched by age and by date of nail return.

    Conclusions 

    Toenail selenium levels were not inversely associated with cancer risk in this study.

    Mots-clés Pascal : Tumeur maligne, Facteur risque, Epidémiologie, Sélénium, Orteil, Ongle, Etats Unis, Amérique du Nord, Amérique, Femelle, Homme

    Mots-clés Pascal anglais : Malignant tumor, Risk factor, Epidemiology, Selenium, Toe, Nail(anatomy), United States, North America, America, Female, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0351968

    Code Inist : 002B04B. Création : 01/03/1996.