Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates.
Chemical-induced hypersensitivity pneumonitis has been so far rarely described.
The purpose of this study was to find out whether hypersensitivity pneumonitis is a common disorder in isocyanate workers.
Company physicians'case histories of 1780 isocyanate workers were evaluated.
In 16 subjects suspected of having isocyanate-induced hypersensitivity pneumonitis, chest x-ray films were made ; level of IgE and IgG antibodies to isocyanate-human serum albumin were estimated ; conjugates and isocyanate challenge tests, bronchoalveolar lavage fluid analyses, and/or lung histologic investigations were performed.
Each of the 14 study patients who had hypersensitivity pneumonitis had work-related dyspnea and fever occurring several hours after the start of work with isocyanates.
Typical clinical findings were the reduction of lung diffusing capacity (n=10), reticular or nodular lung patterns in the r-ray film (n=9), and seem IgG antibodies specific to isocyanate-human serum albumin conjugates (n=10).
Restrictive ventilation patterns in the inhalation challenge tests (n=5), lymphocytic and/or neutrophilic alveolitis seen in bronchoalveolar lavage fluid analyses (n=7), and lymphohistiocytic patterns mostly associated with mild fibrosis in lung histology (n=5) confirmed the diagnosis.
Occupational exposure to isocyanate vapors and aerosols induces typical hypersensitivity pneumonitis in at least 1% of the isocyanate workers with symptoms.
Mots-clés Pascal : Pneumopathie interstitielle, Toxicité, Composé chimique, Allergie, Isocyanate, Exposition professionnelle, Radiographie RX, IgG, Immunoglobuline, Anticorps, Lavage bronchoalvéolaire, Anatomopathologie, Exploration, Diagnostic, Homme, Appareil respiratoire pathologie, Poumon pathologie, Médecine travail, Immunopathologie, Radiodiagnostic
Mots-clés Pascal anglais : Interstitial pneumonitis, Toxicity, Chemical compound, Allergy, Isocyanates, Occupational exposure, X ray radiography, IgG, Immunoglobulins, Antibody, Bronchoalveolar lavage, Pathology, Exploration, Diagnosis, Human, Respiratory disease, Lung disease, Occupational medicine, Immunopathology, Radiodiagnosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0343626
Code Inist : 002B03L06. Création : 01/03/1996.