Restrictive lung disease in rats exposed chronically to an urban profile of ozone.
The potential for irreversible lung impairment resulting from life-long ozone (O3) exposure remains uncertain.
To address this question, young adult rats (male, F-344) were exposed to a simulated urban profile of O3 for 1,3,13,52, or 78 wk, after which pulmonary function tests were performed.
To assess reversibility of effects, cohorts from the 13-52-and 78-wk groups were evaluated, respectively, after an additional 6,27, and 17 wk of clean air.
Static and dynamic lung properties were based on measurements of lung volume apportionment, respiratory system compliance (Crs), DLCO, multibreath N2 washout, and maximum expiratory flow-volume relationships.
Electrocardiography was also performed in unanesthetized, restrained rats after 52 and 78 wk, as were determinations of wet and dry lung weights, lung collagen, and associated connective tissue crosslinks.
Small (<10%) but significant reductions in TLC and RV were noted after 13,52, and 78 wk of O3 exposure.
At 13 and 52 wk, N2 washout was enhanced, though at 78 wk it was similar to control.
None of these changes appeared progressive with continued O3 exposure.
Post exposure to clean air did not completely reverse the reduction in TLC.
Additionally, Crs, though not affected during O3 exposure, decreased during the air recovery.
No O3-related changes in collagen were apparent, however.
Mots-clés Pascal : Pollution air, Ozone, Zone urbaine, Exposition, Réversibilité, Complication, Exploration, Rat, Animal, Modèle animal, Syndrome restrictif, Rodentia, Mammalia, Vertebrata, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Air pollution, Ozone, Urban area, Exposure, Reversibility, Complication, Exploration, Rat, Animal, Animal model, Rodentia, Mammalia, Vertebrata, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0342125
Code Inist : 002B30B02A. Création : 01/03/1996.