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  1. Efficacy and safety and lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol : the dietary intervention study in children (DISC).

    Article - En anglais

    Objective

    - To assess the efficacy and safety of lowering dietary intake of total fat, saturated fat, and cholesterol to decrease low-density lipoprotein cholesterol (LDL-C) levels in children.

    Design

    - Six-center randomized controlled clinical trial.

    Participants

    - Prepubertal boys (n=362) and girls (n=301) aged 8 to 10 years with LDL-C levels greater than or equal to the 80th and less than the 98th percentiles for age and sex were randomized into an intervention group (n=334) and a usual care group (n=329).

    Intervention

    - Behavioral intervention to promote adherence to a diet providing 28% of energy from total fat, less than 8% from saturated fat, up to 9% from polyunsaturated fat, and less than 75 mg/4200 kJ (1000 kcal) per day of cholesterol (not to exceed 150 mg/d).

    Main Outcome Measures

    - The primary efficacy measure was the mean LDL-C level at 3 years.

    Primary safety measures were mean height and serum ferritin levels at 3 years.

    Secondary efficacy outcomes were mean LDL-C levels at 1 year and mean total cholesterol levels at 1 and 3 years.

    Secondary safety outcomes included red blood cell folate values ; serum zinc, retinol, and albumin levels ; serum high-density lipoprotein cholesterol (HDL-C) values, LDL-C :

    • Secondary safety outcomes included red blood cell folate values ;

    • serum zinc, retinol, and albumin levels ;

    • HDL-C ratio, and total triglyceride levels ;

    • sexual maturation ;

    • and psychosocial health.

    Mots-clés Pascal : Cholestérol LDL, Régime alimentaire dépourvu, Graisse, Effet consécutif, Prévention, Epidémiologie, Enfant, Homme

    Mots-clés Pascal anglais : Cholesterol LDL, Deficient diet, Grease, After effect, Prevention, Epidemiology, Child, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0341444

    Code Inist : 002B30A01A2. Création : 01/03/1996.