To examine the relative cost effectiveness of a range of screening and intervention strategies for preventing coronary heart disease in primary care.
Subjects-7840 patients aged 35-64 years who were participants in a trial of modifying coronary heart disease risk factors in primary care.
Design-Effectiveness of interventions assumed and the potential years of life gained estimated from a risk equation calculated from Framingham study data., Main outcome measure-The cost per year of life gained.
THe most cost effective strategy was minimal screening of blood pressure and personal history of vascular disease, which cost £310-£930 per year of life gained for men and £1100-£3460 for women excluding treatment of raised blood pressure.
The extra cost per life year gained by adding smoking history to the screening was £400-£6300 in men.
Lipid lowering drugs accounted for at least 70% of the estimated costs of all strategies.
Cost effectiveness was greatest when drug treatment was limited to those with cholesterol concentrations above 9.5 mmol/l. Conclusions-Universal screening and intervention strategies are an inefficient approach to reducing the coronary heart disease burden.
A basic strategy for screening and intervention, targeted at older men with raised blood pressure and limiting the use of cholesterol lowering drugs to those with very high cholesterol concentrations would be most cost effective.
Mots-clés Pascal : Facteur risque, Appareil circulatoire pathologie, Cardiopathie coronaire, Prévention, Dépistage, Stratégie, Programme sanitaire, Politique sanitaire, Analyse coût efficacité, Angleterre, Grande Bretagne, Royaume Uni, Europe
Mots-clés Pascal anglais : Risk factor, Cardiovascular disease, Coronary heart disease, Prevention, Medical screening, Strategy, Sanitary program, Health policy, Cost efficiency analysis, England, Great Britain, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0336723
Code Inist : 002B30A01C. Création : 01/03/1996.