Contribution of heritable disorders to mortality in the pediatric intensive care unit.
To determine the percentage of patients dying in the pediatric intensive care unit (PICU) who have heritable disorders and to compare vital statistics classification of underlying cause of death with underlying heritable disorder identified from medical record review.
Retrospective medical record review.
The PICU of a university-affiliated hospital.
Medical records were reviewed for all deaths occurring in the PICU over a 5-year period.
Further review, including hospital course, clinical findings, and the presence or absence of a genetic evaluation, was accomplished for those patients found to have a chromosome abnormality, recognized syndrome, single major malformation, or unrecognized syndrome.
Heritable disorders are a frequent cause of mortality in the PICU.
Vital statistics classification of underlying cause of death in this population often fails to identify heritable disorders, leading to an underascertainment of these conditions in mortality statistics.
Improved cause of death classification procedures will be necessary to target public health interventions to etiology-specific populations.
Mots-clés Pascal : Unité soin intensif, Pédiatrie, Nourrisson, Homme, Nouveau né, Epidémiologie, Mortalité, Maladie héréditaire, Arkansas, Etats Unis, Amérique du Nord, Amérique, Maladie congénitale
Mots-clés Pascal anglais : Intensive care unit, Pediatrics, Infant, Human, Newborn, Epidemiology, Mortality, Genetic disease, Arkansas, United States, North America, America, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0334309
Code Inist : 002B27B11. Création : 01/03/1996.