To evaluate the cost-effectiveness of presumptive vaccination versus serological testing of school-age children (6 to 12 years) and adolescents (13 to 17 years) with a negative or uncertain history of varicella.
Decision analysis model based on published and unpublished probabilities and costs.
Hypothetical cohorts of 10 000 school-age children and 10 000 adolescents.
Number of chicken pox cases prevented and cost per chicken pox case prevented.
For school-age children, presumptively vaccinating would prevent 95% of the predicted chicken pox cases, would result in net savings when long-term and work loss costs were included, and would have a similar cost per case prevented as routinely testing before vaccination.
Results for school-age children were sensitive to the probability of previously having had chicken pox given a negative or uncertain history, to the rate of adherence to follow-up visits, and to vaccine price and test price.
Results for adolescents were sensitive only to the rate of adherence to the first follow-up visit.
Presumptively vaccinating all patients with a negative or uncertain history of varicella is projected to be a relatively cost-effective policy for school-age children but not for adolescents.
However, further empirical studies of the accuracy of a negative or uncertain history of chicken pox in these age groups are needed.
Mots-clés Pascal : Varicelle, Virose, Infection, Enfant, Homme, Adolescent, Etude comparative, Sérologie, Vaccination, Economie santé, Analyse coût efficacité, Prévention
Mots-clés Pascal anglais : Varicella, Viral disease, Infection, Child, Human, Adolescent, Comparative study, Serology, Vaccination, Health economy, Cost efficiency analysis, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0334304
Code Inist : 002B05A02. Création : 01/03/1996.