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  1. Cost-effectivenes of varicella serotesting versus presumptive vaccine of school-age children and adolescents.

    Article - En anglais

    Objective

    To evaluate the cost-effectiveness of presumptive vaccination versus serological testing of school-age children (6 to 12 years) and adolescents (13 to 17 years) with a negative or uncertain history of varicella.

    Design

    Decision analysis model based on published and unpublished probabilities and costs.

    Patients

    Hypothetical cohorts of 10 000 school-age children and 10 000 adolescents.

    Main outcome measures

    Number of chicken pox cases prevented and cost per chicken pox case prevented.

    Results

    For school-age children, presumptively vaccinating would prevent 95% of the predicted chicken pox cases, would result in net savings when long-term and work loss costs were included, and would have a similar cost per case prevented as routinely testing before vaccination.

    Results for school-age children were sensitive to the probability of previously having had chicken pox given a negative or uncertain history, to the rate of adherence to follow-up visits, and to vaccine price and test price.

    Results for adolescents were sensitive only to the rate of adherence to the first follow-up visit.

    Conclusions

    Presumptively vaccinating all patients with a negative or uncertain history of varicella is projected to be a relatively cost-effective policy for school-age children but not for adolescents.

    However, further empirical studies of the accuracy of a negative or uncertain history of chicken pox in these age groups are needed.

    Mots-clés Pascal : Varicelle, Virose, Infection, Enfant, Homme, Adolescent, Etude comparative, Sérologie, Vaccination, Economie santé, Analyse coût efficacité, Prévention

    Mots-clés Pascal anglais : Varicella, Viral disease, Infection, Child, Human, Adolescent, Comparative study, Serology, Vaccination, Health economy, Cost efficiency analysis, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0334304

    Code Inist : 002B05A02. Création : 01/03/1996.