Vasectomy, a widely used form of contraception, has been associated in some studies with increased prostate cancer risk.
We assessed this association on the basis of data collected in a large multiethnic case-control study of prostate cancer that was conducted in the United States Los Angeles, San Francisco, and Hawaii) and Canada Toronto and Vancouver).
The present analysis was based on 1642 prostate cancer patients and 1636 control subjects.
A history of vasectomy was not significantly associated with prostate cancer risk among all racial/ethnic groups.
Among Japanese-Americans, the OR was 1.8 (95% CI=0.97-3.4), but the statistically nonsignificant elevation in risk was limited to more educated men and those with localized cancers.
ORs did not vary signifcantly by age at vasectomy or years since vasectomy.
We found a lower serum concentration of sex hormone-binding globulin and a higher ratio of dihydrotestosterone to testosterone among vasectomized control subjects than among nonvasectomized control subjects.
The findings of this study do not support previous reports of increased prostate cancer risk associated with vasectomy.
However, the altered endocrine profiles of vasectomized control subjects seen in this cross-sectional comparison warrant further evaluation in longitudinal studies.
Mots-clés Pascal : Tumeur maligne, Prostate, Facteur risque, Epidémiologie, Vasectomie, Contraception, Ethnie, Etats Unis, Amérique du Nord, Amérique, Canada, Homme, Prostate pathologie, Appareil urinaire pathologie, Appareil génital mâle pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Prostate, Risk factor, Epidemiology, Vasectomy, Contraception, Ethnic group, United States, North America, America, Canada, Human, Prostate disease, Urinary system disease, Male genital diseases, Case control study
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0333050
Code Inist : 002B14D02. Création : 01/03/1996.