Non-A, non-B is a major form of hepatitis in haemodialysis (HD) patients.
Hepatitis C virus (HCV) has been recently identified as the leading cause of non-A, non-B hepatitis in HD.
A variable prevalence of hepatitis in HD has appeared in the literature, ranging between 1% and 29% in the Western world, and between 30% and 54% in Saudi Arabia, but all these reports used first-generation ELISA.
Using second-generation enzyme immunoassay, we conducted a multi-centre study involving 22 HD centres all over Saudi Arabia in order to establish the prevalence and risk factors for HCV in HD patients in Saudi Arabia.
A total of 1147 patients were studied, with a mean age of 43.4±15.3 years.
Five hundred and eighty were males and 567 were females.
HCV antibodies were found more frequently in Egyptians, Pakistanis and Yemenis than in Saudis.
A comparison between those centres with low prevalence of positive HCV and those with high prevalence regarding risk factors was carried out, and it was found that the major difference between them was the adherence of the staff to universal infection precautions.
In conclusion, HCV is a major health problem in HD patients in Saudi Arabia.
Identifiable risk factors are longer duration in dialysis, blood transfusion, male sex, nationality and most importantly the lack of adherence to universal infection precautions.
Mots-clés Pascal : Hémodialyse, Hépatite virale C, Virose, Infection, Prévalence, Facteur risque, Epidémiologie, Homme, Arabie Saoudite, Asie, Epuration extrarénale, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Hemodialysis, Viral hepatitis C, Viral disease, Infection, Prevalence, Risk factor, Epidemiology, Human, Saudi Arabia, Asia, Extrarenal dialysis, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0328269
Code Inist : 002B27B03. Création : 01/03/1996.