In a search for clues to the origin of squamous cell skin cancer (SCC), the authors investigated the pattern of new cancers in a cohort of 5,100 SCC patients whose tumors were diagnosed during the years 1978-1989 and recorded in the Danish Cancer Registry.
Subsequent cancer experiences in SCC patients were compared with the cancer incidence in the Danish population using ratios of observed cancew to expected cancers as a measure of the relative risk.
Overall, patients with SCC were at increased risk of new malignancies (relative risk (RR)=1.6,95% confidence interval (CI) 1.5-1.7).
Significantly elevated risks were found for cancers of the respiratory organs (RR=1.7,95% CI 1.4-2.0) ; cancers of the lip, buccal cavity, and pharynx (RR=3.1,95% CI 2.1-4.5) ; non-Hodgkin's lymphoma (RR=2.3,95% CI 1.4-3.5) ; leukemia (RR=2.5,95% CI 1.7-3.5) ; malignant melanoma (RR=2.6,95% CI 1.5-4.3) ; and cancer of the small intestine in men (RR=4.1,95% CI 1.1-10.6).
The risk of new cancers (other than nonmelanoma skin cancers) was higher in patients diagnosed with SCC before the age of 60 years (RR=1.9,95% CI 1.5-2.5) than in those diagnosed with SCC at or after that age (RR=1.3,95% CI 1.2-1.4).
The data confirmed previous strong associations between SCC and malignant melanoma and cancers of the major salivary glands.
Mots-clés Pascal : Epithélioma spinocellulaire, Peau, Homme, Epidémiologie, Association, Leucémie, Lymphome, Second cancer, Facteur risque, Danemark, Europe, Tumeur maligne, Peau pathologie, Hémopathie maligne
Mots-clés Pascal anglais : Squamous cell carcinoma, Skin, Human, Epidemiology, Association, Leukemia, Lymphoma, Second cancer, Risk factor, Denmark, Europe, Malignant tumor, Skin disease, Malignant hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0321782
Code Inist : 002B08A. Création : 01/03/1996.