Increased risk of craniosynostosis with higher antenatal maternal altitude.
During the 1980s, the Colorado Department of Health received reports from several high-altitude communities of clusters of the malformation craniosynostosis.
In a population-based, case-control study, we examined the association between overall and trimester-specific maternal antenatal altitude exposure and the occurrence of infant craniosynostosis.
We identified case children through a statewide registry and randomly sampled control children from birth records.
By telephone interview, each mother provided data on the locations of all antenatal residences and places of employment as well as other factors.
Staff mapped all locations and abstracted the corresponding altitudes.
The odds ratio (OR) of any synostosis for a time-weighted mean antenatal altitude of =2000 metres versus <2000 metres was 1.4 (lower bound of the one-sided 95% test-based confidence interval (CI) : 0.9).
The OR was elevated in smokers but not in non-smokers.
As compared to non-smokers, the OR of any synostosis for high-altitude smokers was 4.6 .Particularly elevated were the correspondinding OR of coronal (18.1,4.4) and metopic synostosis (16.3,2.8), and OR for high-altitude exposure during the second trimester (any synostosis : 6.4,1.99 ; coronal : 28.6,6.1 ; metopic : 26.7,4.1).
Antenatal maternal high-altitude exposure and smoking are associated with increased risk of infant craniosynostosis, perhaps through generation of intermittent hypoxaemia.
Mots-clés Pascal : Tératologie, Altitude, Mère, Gestation, Femme, Homme, Crâniosynostose, Malformation, Epidémiologie, Descendance, Nourrisson, Colorado, Etats Unis, Amérique du Nord, Amérique, Système ostéoarticulaire pathologie, Dysostose, Système nerveux pathologie, Crâne pathologie
Mots-clés Pascal anglais : Teratology, Altitude, Mother, Pregnancy, Woman, Human, Craniosynostosis, Malformation, Epidemiology, Progeny, Infant, Colorado, United States, North America, America, Diseases of the osteoarticular system, Dysostosis, Nervous system diseases, Skull disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0318074
Code Inist : 002A30E. Création : 01/03/1996.