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  1. Cancer incidence in a group of workers potentially exposed to ethylene oxide.

    Article - En anglais

    Background

    Cytogenetic changes associated with ethylene oxide (ETO) exposure at a worksite prompted a study of cancer incidence in that cohort.

    Method

    Cancer incidence through 31 December 1987 was ascertained in a cohort of 1132 individuals employed at the worksite at any time from 1 July 1974 through 30 September 1980, the period of potential exposure to ETO at the plant.

    The number of observed cancers was compared with that expected based on age-and sex-specific incidence rates reported by the National Cancer Institute's Surveillance Epidemiology and End Results Program.

    Standardized morbidity ratios (SMR) were calculated separately for regular and temporary employees.

    Results

    Of the 28 cancers observed in the cohort, 12 were breast cancers.

    The SMR for breast cancer among regular female employees ranged from 2.55 (95% CI : 1.31-4.98, P=0.02) to 1.70 (95% CI : 0.89-3.23, P=0.09) depending on calendar year of follow-up, assumptions about completeness of follow-up, and the reference rates used.

    No increase in cancer incidence was found over that expected for any cancer sites associated with ETO in previous studies-leukaemia, brain, pancreas and stomach.

    Conclusions

    Factors such as appropriateness of latency periods, length of follow-up and lack of a common histopathological type need to be considered in evaluating the excesses in observed breast cancer incidence, which diminished over time.

    Mots-clés Pascal : Gaz, Stérilisation chimique, Oxirane, Exposition professionnelle, Homme, Carcinogène, Age, Sexe, Tumeur maligne, Glande mammaire pathologie, Glande mammaire, Etude longitudinale, Etats Unis, Amérique du Nord, Amérique, Médecine travail, Hémopathie

    Mots-clés Pascal anglais : Gases, Chemical sterilization, Ethylene oxide, Occupational exposure, Human, Carcinogen, Age, Sex, Malignant tumor, Mammary gland diseases, Mammary gland, Follow up study, United States, North America, America, Occupational medicine, Hemopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0318048

    Code Inist : 002B03L02. Création : 01/03/1996.