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  1. HPV infection in cervical-cancer cases in Russia.

    Article - En anglais

    The presence of human papillomavirus (HPV) sequences in 21 biopsies from cervical carcinomas, 11 specimens of tissues adjacent to tumours, 2 specimens of cervical tissues with radiation fibrosis from patients after radiation therapy of cervical cancer and 7 normal epithelial tissues from the patients with other genital tumours were examined by polymerase chain reaction (PCR) and Southern-blot analysis.

    All tumours were HPV-positive by type-specific PCR and 86% by Southern-blot analysis.

    In normal epithelial and adjacent tissues, HPV sequences were detected in 20% of samples by Southern-blot analysis and in 70% of samples by PCR, including 2 cases of tissues after radiation therapy.

    HPV16 was the most prevalent type in tumours (18/21) as well as in normal epithelial tissues (5/7).

    One HPV-positive tumour contained HPV18 DNA and 2 were doubly infected with HPVs 16 and 18 (2/21).

    The persistence of exclusively episomal HPV16 DNA was observed in 5 out of 11 tumours examined : 3 cases of squamous-cell carcinomas on the early stage of tumour progression and 2 advanced tumours (squamous-cell carcinoma and adenocarcinoma).

    The integration of HPV16 genome was detected in 6 out of 11 tumours, but most of them contained episomal forms of viral DNA simultaneously (5 out of 6).

    The integrative HPV18 genome was found in 2 tumours examined, and the persistence of episomal forms was also observed in one of them.

    Mots-clés Pascal : Epithélioma, Col utérus, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Biologie moléculaire, Exploration, Prévalence, Epidémiologie, Homme, Femelle, Russie, Eurasie, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Molecular biology, Exploration, Prevalence, Epidemiology, Human, Female, Russia, Eurasia, Female genital diseases, Uterine cervix diseases, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0282890

    Code Inist : 002B20C02. Création : 01/03/1996.