This article deals with some of the recent evidence bearing on the issues of the liability of benzodiazepines to lead to abuse, dependence, and adverse behavioral effects.
Reviews of epidemiologicnl, clinical and experimental literature indicated that the previous conclusion about abuse of these drugs still holds : the vast majority of the use of benzodiazepines is appropriate.
Problems of nonmedical use arise nearly exclusively among people who abuse other drugs.
Nevertheless, there are reasons for concern about patients who take benzodiazepines regularly for long periods of time.
These drugs can produce physiological dependence when taken chronicaly, and although this does not appear to result in dose escalation or other evidence of « psychological dependence, » physiological dependence can result in patient discomfort if drug use is abruptly discontiniued.
Also, physicians are currently prescribing shorter-acting benzodiazepines in preference to longer-acting benzodiazepines.
The shorter-acting drugs can produce a more intense withdrawal syndrome following chronic administration.
Furthermore, rates of use of benzodiazepines increase with age, and elderly patients are more likely than younger ones to take the drug chronically.
The clearest adverse effect of benzodiazepines is impairment of memory.
Mots-clés Pascal : Benzodiazépine dérivé, Hypnotique, Psychotrope, Tranquillisant, Toxicité, Animal, Homme, Rythme administration, Epidémiologie, Dépendance, Prescription médicale, Consommation
Mots-clés Pascal anglais : Benzodiazepine derivatives, Hypnotic, Psychotropic, Tranquillizer, Toxicity, Animal, Human, Administration schedule, Epidemiology, Dependence, Medical prescription, Consumption
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0277274
Code Inist : 002B02U10. Création : 01/03/1996.