The relationships between reproductive factors, exogenous hormones and renal-cell cancer were examined in an international, multicenter, population-based, case-control study undertaken in 1989-1991.
Data from 5 centers situated in Australia, Dennmark, Germany, Sweden and the United States included for analysis 608 women with renal-cell cancer and 766 female controls.
A significant trend in risk (p=0.002) was associated with number of births, with an 80% excess risk for 6 or more births [RR=1.8,95% confidence interval (CI)=1.1 to 2.9] compared with one birth, although this was confounded by body-mass index and number of births.
A suggestive reduction of risk was also seen for increasing age at menarche.
Age at menopause was unrelated to risk of renal-cell cancer.
An increased risk was observed for women having had both a hysterectomy and an oophorectomy.
Use of oral contraceptives in non-smoking women reduced the risk of renal-cell cancer (RR=0.5,95% CI=0.4 to 0.8) ; this reduction increased with longer duration of use.
No association was observed for estrogen replacement therapy.
Our results indicate that certain hormonal and reproductive variables may be related ro risk of renal-cell cancer and deserve further investigation, both epidemiologically and experimentally.
Mots-clés Pascal : Hypernéphrome, Homme, Femelle, Epidémiologie, Facteur risque, Antécédent, Chirurgie, Appareil génital femelle, Contraception, Voie orale, Hormone stéroïde sexuelle, Parité, Etude multicentrique, Echelon international, Epithélioma, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne
Mots-clés Pascal anglais : Grawitz tumor, Human, Female, Epidemiology, Risk factor, Antecedent, Surgery, Female genital system, Contraception, Oral administration, Sex steroid hormone, Parity, Multicenter study, International scope, Carcinoma, Urinary system disease, Renal disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0271602
Code Inist : 002B14D01. Création : 01/03/1996.