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  1. T-cell malignancies in Brazil. Clinico-pathological and molecular studies of HTLV-I-positive and - negative cases.

    Article - En anglais

    T-cell malignancies in Brazil have a high seroprevalence rate of HTLV-1 antibodies.

    We have analyzed the disease features in 188 Brazilian patients with a T-cell disorder.

    These included 40 with T-lymphoblastic leukaemia or lymphoma (T-ALL/T-LbLy) and 148 with mature T-cell diseases : 5 T-prolymphocytic leukaemia, 53 adult T-cell leukaemia/lymphoma (ATLL), 54 cutaneous T-cell lymphomas, 29 pleomorphic T-cell lymphomas and 7 large granular lymphocyte leukaemia.

    The diagnosis was based on clinical, morphological and immunological features and HTLV-1 serology.

    ATLL in Brazil has the same disease features as in other endemic regions, the only apparent differences being : age, Brazilian patients being younger than japanese, and ethnic grouping, one third of Brazilians being white Caucasians of European descent.

    We applied a scoring system based on the presence or absence of typical features associated with ATLL : hypercalcaemia, cell morphology, immunophenotype, histopathology and HTLV-1 status, to see whether it may help in diagnosing cases of ATLL.

    All had high scores, whereas all other T-cell diseases scored low.

    Only 5 ATLL cases were HTLV-1-negative by serology, but they had otherwise typical features of ATLL, and their cells did not have HTLV-1 proviral sequences by DNA analysis.

    Mots-clés Pascal : Leucémie cellule T adulte, Virose, Infection, Lymphome, Lymphocyte T, Symptomatologie, Homme, Exploration, Virus HTLV1, Retroviridae, Virus, Sérologie, Biologie moléculaire, Cellule tumorale, Phénotype, Brésil, Amérique du Sud, Amérique, Hémopathie maligne, Lymphoprolifératif syndrome, Lymphome non hodgkinien, Type histologique

    Mots-clés Pascal anglais : Adult T cell leukemia, Viral disease, Infection, Lymphoma, T-Lymphocyte, Symptomatology, Human, Exploration, HTLV-I virus, Retroviridae, Virus, Serology, Molecular biology, Tumor cell, Phenotype, Brazil, South America, America, Malignant hemopathy, Lymphoproliferative syndrome, Non Hodgkin lymphoma, Histological type

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0264018

    Code Inist : 002B19B. Création : 01/03/1996.