Cardiovascular disease is the most common cause of death in dialysis subjects.
Congestive heart failure (CHF) is a common presenting symptom of cardiovascular disease in the dialysis population.
Information regarding prevalence, incidence, risk factors and prognosis is crucial for planning rational interventional studies.
A prospective multicenter cohort study of 432 dialysis patients followed for a mean of 41 months was carried out.
Prospective information on a variety of risk factors was collected.
Annual echocardiography and clinical assessment was performed.
Major endpoints included death and the development of morbid cardiovascular events.
One hundred and thirty-three (31%) subjects had CHF at the time of initiation of dialysis therapy.
Multivariate analysis showed that the following risk factors were significantly and independently associated with CHF at baseline : systolic dysfunction, older age, diabetes mellitus and ischemic heart disease.
Seventy-six of 299 subjects (25%) who did not have baseline CHF subsequently developed CHF during their course on dialysis.
Compared to those subjects who never developed CHF (N=218) multivariate analysis identified the following risk factors for the development of CHF : older age, anemia during dialysis therapy, hypoalbuminemia, hypertension during dialysis therapy, and systolic dysfunction.
Seventy-five of the 133 (56%) subjects with CHF at haseline had recurrent CHF during follow-up.
Mots-clés Pascal : Insuffisance rénale, Chronique, Stade terminal, Epuration extrarénale, Homme, Complication, Insuffisance cardiaque, Prévalence, Incidence, Pronostic, Facteur risque, Epidémiologie, Appareil urinaire pathologie, Rein pathologie, Néphropathie, Appareil circulatoire pathologie, Cardiopathie
Mots-clés Pascal anglais : Renal failure, Chronic, Terminal stade, Extrarenal dialysis, Human, Complication, Heart failure, Prevalence, Incidence, Prognosis, Risk factor, Epidemiology, Urinary system disease, Renal disease, Nephropathy, Cardiovascular disease, Heart disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0254966
Code Inist : 002B14A05. Création : 01/03/1996.