In order to clarify the bioavailability of lead in plasma (PbP), we performed a study on five workers in a Japanese factory manufacturing lead glass-based paints.
Blood and urine samples were obtained over a period of 15 months, during which time the workers took it in turns to perform sifting work (with the highest level of lead exposure) for 1-month periods.
A total of 75 sets of blood and urine samples were thus obtained.
We determined whole blood lead (PbB), PbP, Urinary coproporphyrin (CPU), urinary b-aminolevulinic acid (ALAU), urinary lead (PbU) and ALA in plasma (ALAP).
In the 15 sets of samples obtained at the end of the period with a high level of lead exposure, PbP correlated significantly with ALAU, CPU, PbU and ALAP, but PbB correlated significantly only with PbU.
In the 60 sets of samples obtained following a low level of lead exposure, correlation coefficients between the concentrations of PbP and of ALAU, CPU and PbU exceeded those between the concentrations of PbB and of ALAU, CPU and PbU.
These findings indicate that PbP is a better dose indicator of lead biochemically available for heme synthesis and that PbU has a closer correlation with PbP than with PbB.
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Homme, Industrie, Biodisponibilité, Japon, Asie, Industrie verre, Surveillance biologique, Urine, Liquide biologique, Hème, Marqueur biologique, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Médecine travail, Plasma sanguin, Sang total
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Human, Industry, Bioavailability, Japan, Asia, Glass industry, Biological monitoring, Urine, Biological fluid, Heme, Biological marker, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Enzyme, Occupational medicine, Blood plasma, Whole blood
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0044495
Code Inist : 002B03L05. Création : 01/03/1996.