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  1. HLA-DPB1 polymorphism in patients with rheumatoid arthritis in Taiwan.

    Article - En anglais

    T. Objective.

    To investigate the role of HLA-DP alleles in the pathogenesis of rheumatoid arthritis (RA).


    HLA-DPBI alleles were studied in 144 patients with RA and 144 healthy controls using the polymerase chain reaction/sequence specific oligonucleotide probe method.


    HLA-DPB1*0501 was the most common allele in patients with RA and healthy controls in Taiwan.

    There was no significant difference in frequencies of HLA-DPBI alleles between patients and controls.

    The HLA-DPB1 alleles were not associated with seropositivity for rheumatoid factor, extraarticular involvement, or bone erosion in patients.

    There was also no significant difference in frequencies of HLA-DPBI alleles among DR4-positive and DR4-negative patients and controls.


    There was no significant difference in the prevalences of HLA-DPBI alleles between Taiwanese patients with RA and healthy controls.

    HLA-DPBI alleles were not related to the clinical manifestations of patients with RA in Taiwan.

    Mots-clés Pascal : Polyarthrite rhumatoïde, Chronique, Maladie autoimmune, Rhumatisme inflammatoire, Immunopathologie, Système ostéoarticulaire pathologie, Déterminisme génétique, Epidémiologie, Homme, Système histocompatibilité majeur, Système HLA-DR, Phénotype, Taiwan, Asie, Antigène histocompatibilité classe II, Polymorphisme, Gène

    Mots-clés Pascal anglais : Rheumatoid arthritis, Chronic, Autoimmune disease, Inflammatory joint disease, Immunopathology, Diseases of the osteoarticular system, Genetic inheritance, Epidemiology, Human, Major histocompatibility system, HLA-DR-System, Phenotype, Taiwan, Asia, Class II histocompatibility antigen, Polymorphism, Gene

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0041214

    Code Inist : 002B15D. Création : 01/03/1996.