To investigate the role of HLA-DP alleles in the pathogenesis of rheumatoid arthritis (RA).
HLA-DPBI alleles were studied in 144 patients with RA and 144 healthy controls using the polymerase chain reaction/sequence specific oligonucleotide probe method.
HLA-DPB1*0501 was the most common allele in patients with RA and healthy controls in Taiwan.
There was no significant difference in frequencies of HLA-DPBI alleles between patients and controls.
The HLA-DPB1 alleles were not associated with seropositivity for rheumatoid factor, extraarticular involvement, or bone erosion in patients.
There was also no significant difference in frequencies of HLA-DPBI alleles among DR4-positive and DR4-negative patients and controls.
There was no significant difference in the prevalences of HLA-DPBI alleles between Taiwanese patients with RA and healthy controls.
HLA-DPBI alleles were not related to the clinical manifestations of patients with RA in Taiwan.
Mots-clés Pascal : Polyarthrite rhumatoïde, Chronique, Maladie autoimmune, Rhumatisme inflammatoire, Immunopathologie, Système ostéoarticulaire pathologie, Déterminisme génétique, Epidémiologie, Homme, Système histocompatibilité majeur, Système HLA-DR, Phénotype, Taiwan, Asie, Antigène histocompatibilité classe II, Polymorphisme, Gène
Mots-clés Pascal anglais : Rheumatoid arthritis, Chronic, Autoimmune disease, Inflammatory joint disease, Immunopathology, Diseases of the osteoarticular system, Genetic inheritance, Epidemiology, Human, Major histocompatibility system, HLA-DR-System, Phenotype, Taiwan, Asia, Class II histocompatibility antigen, Polymorphism, Gene
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0041214
Code Inist : 002B15D. Création : 01/03/1996.