Epidemiology of presenile Alzheimer's disease in Scotland (1974-88). I : Non-random geographical variation.
Factors that determine geographical differences in incidence rates of'probable'presenile Alzheimer's disease (AD PSD) may help to clarify the possible role of the environment in its aetiology.
We have ascertained the treated incidence of AD PSD in Scotland by scrutiny of hospital casenotes and searched for cases outside hospital settings.
Small area geographical analysis compared the observed distribution of cases (each allocated to one of Scotland's 898 postcode sectors) with the estimated random distribution of cases.
There was non-random geographical distribution of AD PSD but not of the comparison conditions (vascular dementia (VaD), motor neurone disease, prostatic or ovarian cancers).
Substantial differences between Scottish regions were probably not attributable to methodological artefact, as other techniques of case finding showed the same regional differences.
The observed differences in incidence of AD PSD between Scotland's regions are real and some localities have a higher incidence, mostly in central Scotland.
Mots-clés Pascal : Démence présénile, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Incidence, Epidémiologie, Ecosse, Grande Bretagne, Royaume Uni, Europe, Etude longitudinale, Variation géographique, Facteur risque, Adulte, Homme
Mots-clés Pascal anglais : Presenile dementia, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Incidence, Epidemiology, Scotland, Great Britain, United Kingdom, Europe, Follow up study, Geographical variation, Risk factor, Adult, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0040640
Code Inist : 002B17G. Création : 01/03/1996.