We related geographical variation of'probable'presenile Alzheimer's disease (AD PSD) to exposures to possible risk factors for AD PSD and vascular dementia (VaD) and to geographical differences in survival times after presentation with AD PSD.
We found that an ecological measure of socio-economic deprivation was related to VaD but not to AD PSD.
Among men with AD PSD and VaD, specific occupations conveyed no altered risk but having fathers who were coal miners was associated with AD PSD and VaD in offspring.
Increased paternal age was associated with AD PSD but only in men.
These factors acted independently of one another and did not distinguish between geographical areas of high and low incidence.
The length of survival after presentation with AD PSD distinguished between these areas, and when migration between these areas was taken into account, a plausible multifactorial model of the harmful effects of environment emerged, which acted independently of risk factors acting earlier in life.
Mots-clés Pascal : Démence présénile, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Incidence, Epidémiologie, Ecosse, Grande Bretagne, Royaume Uni, Europe, Variation géographique, Facteur risque, Statut social, Environnement social, Statut professionnel, Père, Changement domicile, Adulte, Homme
Mots-clés Pascal anglais : Presenile dementia, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Incidence, Epidemiology, Scotland, Great Britain, United Kingdom, Europe, Geographical variation, Risk factor, Social status, Social environment, Professional status, Father, Domicile change, Adult, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0040589
Code Inist : 002B17G. Création : 01/03/1996.