We conducted an exploratory study of brain tumors that occurred as a second primary malignancy to identify potential risk factors for brain tumors.
Using data from the Surveillance, Epidemiology, and End Results (SEER) Program, we calculated the sex-specific standardized incidence ratio (SIR), adjusted to age and time period, as an estimate of the relative risk (RR) of developing a second primary brain tumor following other cancers.
We found an elevated RR of brain tumors after bladder cancer in both men (RR, 1.7 ; 95% confidence interval [CI], 1.2 to 2.3) and women (RR, 1.7 ; 95% CI, 0.8 to 3.2) ; this effect was present for both astrocytoma and glioblastoma multiforme.
Elevated RRs of brain tumors were also found after sarcoma (RR, 4.4 ; 95% CI, 1.8 to 9.0) and leukemia (RR, 2.9 ; 95% CI, 1.6 to 4.8) in men, and after colorectal cancer (RR, 1.8 ; 95% CI, 1.3 to 2.4) and endometrial cancer (RR, 1.4 ; 95% CI, 1.0 to 1.9) in women.
The highest RR observed in this study was for CNS lymphoma following any first primary malignancy in men (RR, 7.9 ; 95% CI, 5.5 to 11.0).
The associations of brain tumors with bladder, colorectal, and endometrial cancers in women, and an increased occurrence of CNS lymphoma as a second malignancy in men, are new findings that have not been described previously.
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Intracrânien, Second cancer, Association, Homme, Incidence, Analyse risque, Epidémiologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Intracranial, Second cancer, Association, Human, Incidence, Risk analysis, Epidemiology, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0037974
Code Inist : 002B17E. Création : 01/03/1996.