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  1. Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.

    Article - En anglais

    Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan.

    We studied VHL gene mutation in 31 kidney tumors from France.

    Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A : T base pairs.

    The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations.

    Mots-clés Pascal : Hypernéphrome, Homme, Gène suppresseur tumeur, Mutation somatique, Exploration, Carcinogenèse, Pathogénie, France, Europe, Epidémiologie, Carcinome, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Gène von Hippel Lindau

    Mots-clés Pascal anglais : Grawitz tumor, Human, Tumor suppressor gene, Somatic mutation, Exploration, Carcinogenesis, Pathogenesis, France, Europe, Epidemiology, Carcinoma, Urinary system disease, Renal disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0034525

    Code Inist : 002B14D01. Création : 01/03/1996.