To investigate the rate and extent of infection by Epstein-Barr virus (EBV), cytomegalovirus, and herpesvirus 6 in families (affected and nonaffected members) with multiple cases of rheumatoid arthritis (RA).
Viral DNA was detected by polymerase chain amplification in cells from saliva and peripheral blood.
Human leukocyte antigen pedigrees were characterized.
Viral DNA, particularly EBV, was detected in increased frequency (p=0.029) in the patients with RA compared to their nonaffected relatives.
We suggest that in RA multicase families, increased frequency of viral infection is likely a consequence of the disease state and/or due to gene (s) as yet unidentified.
Mots-clés Pascal : Polyarthrite rhumatoïde, Chronique, Maladie autoimmune, Rhumatisme inflammatoire, Immunopathologie, Système ostéoarticulaire pathologie, Association, Epidémiologie, Homme, Etude familiale, Virose, Infection, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Cytomegalovirus humain, Betaherpesvirinae, Herpesvirus hominis 6
Mots-clés Pascal anglais : Rheumatoid arthritis, Chronic, Autoimmune disease, Inflammatory joint disease, Immunopathology, Diseases of the osteoarticular system, Association, Epidemiology, Human, Family study, Viral disease, Infection, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Human cytomegalovirus, Betaherpesvirinae, Herpesvirus hominis 6
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0027519
Code Inist : 002B15D. Création : 01/03/1996.