We report the results of a national quality-control survey on glycohemoglobin (GHb), monitored in France by the Société Française de Biologie Clinique on behalf of the authority of the « Agence du Medicament. » A sample of lyophilized hemolysate was sent to 3109 laboratories.
Results were obtained from 2770 laboratories.
HbA1c, HbA1, and total GHb were measured by 50%, 24%, and 26% of the participants, respectively.
Of these measurements, 79% of the HbA1c results and 76% of the total GHb results, but only 48% of the HbA1 results, were within the ± 20% limits of the indicated target values.
Mean values for the hemolysate ranged from 8% to 11% for HbA1c, from 7% to 12% for HbA1, and from 11% to 13% for total GHb.
The interlaboratory CVs ranged from 3% to 20%, according to method used.
So, methods used for GHb assay, which are based on various principles, exhibit very different analytical performances.
Nonetheless, this large-scale study indicates that some techniques can support transferability of results from laboratory to laboratory.
Mots-clés Pascal : Hémoglobine A1, Analyse quantitative, Contrôle qualité, Homme, France, Europe, Etude comparative, Méthode, Référence, Biologie clinique
Mots-clés Pascal anglais : Hemoglobin A1, Quantitative analysis, Quality control, Human, France, Europe, Comparative study, Method, Reference, Clinical biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0026662
Code Inist : 002A02D04A. Création : 01/03/1996.