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  1. Fulltext. Glycohemoglobin assays evaluated in a large-scale quality-control survey.

    Article - En anglais


    We report the results of a national quality-control survey on glycohemoglobin (GHb), monitored in France by the Société Française de Biologie Clinique on behalf of the authority of the « Agence du Medicament. » A sample of lyophilized hemolysate was sent to 3109 laboratories.

    Results were obtained from 2770 laboratories.

    HbA1c, HbA1, and total GHb were measured by 50%, 24%, and 26% of the participants, respectively.

    Of these measurements, 79% of the HbA1c results and 76% of the total GHb results, but only 48% of the HbA1 results, were within the ± 20% limits of the indicated target values.

    Mean values for the hemolysate ranged from 8% to 11% for HbA1c, from 7% to 12% for HbA1, and from 11% to 13% for total GHb.

    The interlaboratory CVs ranged from 3% to 20%, according to method used.

    So, methods used for GHb assay, which are based on various principles, exhibit very different analytical performances.

    Nonetheless, this large-scale study indicates that some techniques can support transferability of results from laboratory to laboratory.

    Mots-clés Pascal : Hémoglobine A1, Analyse quantitative, Contrôle qualité, Homme, France, Europe, Etude comparative, Méthode, Référence, Biologie clinique

    Mots-clés Pascal anglais : Hemoglobin A1, Quantitative analysis, Quality control, Human, France, Europe, Comparative study, Method, Reference, Clinical biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0026662

    Code Inist : 002A02D04A. Création : 01/03/1996.