Serum concentrations of apolipoprotein (apo) A-I, apo B, and lipoprotein (a) [Lp (a) ] were studied with respect to age and sex in a Finnish population sample of 575 subjects (286 men and 289 women), ages 27-67 years.
Apo A-I and apo B were measured with an immunoturbidimetric method calibrated against WHO International Reference Materials.
Lp (a) was measured by RIA.
Apo A-I and apo B concentrations were almost normally distributed (apo A-I : mean 1.38 g/L vs median 1.34 g/L for men, and 1.58 g/L vs 1.55 g/L for women ; apo B : mean 1.21 g/L vs median 1.20 g/L for men and 1.09 g/L vs 1.05 g/L for women).
The distribution of Lp (a) was remarkably skewed (mean 190 mg/L vs median 86 mg/L for men, and 169 mg/L vs 85 mg/L for women).
The 95% intervals for apo A-I were 1.09-1.84 g/L for men and 1.06-2.28 g/L for women ; for apo B, they were 0.63-1.88 g/L and 0.56-1.82 g/L, respectively.
Apo A-I concentrations appeared to be unrelated to age, whereas apo B and Lp (a) concentrations were age-dependent.
Cutoff values based on the 90th percentile for apo B and the 10th percentile for apo A-I are proposed for identifying subjects at increased risk of coronary heart disease.
Mots-clés Pascal : Apolipoprotéine B, Sérum, Analyse quantitative, Age, Dimorphisme sexuel, Etude comparative, Finlande, Europe, Epidémiologie, Homme, Liquide biologique, Apolipoprotéine AI, Lipoprotéine a
Mots-clés Pascal anglais : Apolipoprotein B, Serum, Quantitative analysis, Age, Sexual dimorphism, Comparative study, Finland, Europe, Epidemiology, Human, Biological fluid, Apolipoprotein AI, a Lipoprotein
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0026660
Code Inist : 002B22A. Création : 01/03/1996.