In 1991, Dubach et al clearly demonstrated an increased risk of renal morbidity and mortality after phenacetin abuse in middle aged working women.
We investigated the renal effects of the abuse of several kinds of analgesics in abusers of different sex and age categories.
A cohort of 200 active analgesic abusers (age range 21 to 86 years) and 200 matched controls was followed for seven years (1984 to 1992).
Subjects were visited at home once a year for a short interview and a medical examination.
Renal function showed a significant decrease over time in controls as well as in abusers (P<0.001).
The decrease was, however, significantly more pronounced in abusers (P<0.001).
The development of a decreased renal function was observed in 12 abusers and 2 controls resulting in a relative risk of 6.1 (95% CI : 1.4 to 25.9).
Subjects showing a decreased renal function underwent a diagnostic investigation.
Using validated diagnostic criteria, analgesic nephropathy could be established in 6 out of the l0 abusers who had a diagnostic workup, in the absence of any other form of renal disease.
Mots-clés Pascal : Insuffisance rénale, Homme, Analgésique, Abus médicamenteux, Néphropathie, Toxicité, Etude longitudinale, Etude cohorte, Belgique, Europe, Epidémiologie, Analyse risque, Appareil urinaire pathologie, Rein pathologie
Mots-clés Pascal anglais : Renal failure, Human, Analgesic, Drug abuse, Nephropathy, Toxicity, Follow up study, Cohort study, Belgium, Europe, Epidemiology, Risk analysis, Urinary system disease, Renal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0025385
Code Inist : 002B02V. Création : 01/03/1996.