The authors investigated the role of secondary immunologic response, virus serotype, age, and sex on the clinical manifestations of dengue fever in Puerto Rico.
From surveillance data for 1990 and 1991, this study identified 3,926 laboratory-positive cases, including 889 for whom dengue immunologic status and symptoms could be ascertained.
Of those, 622 cases were virologically confirmed, and 267 cases were serologically confirmed.
More than 50% of all positive patients reported fever, chills, headache, eye pain, body pains, joint pains, nausea, vomiting, or skin rash.
The frequency of reporting signs, symptoms, and hospitalization was significantly higher among persons with secondary infections diagnosed by serologic methods.
Only rash was more common among those with primary infections.
Symptom reporting increased with age ; body pains, joint pains, and rash were significantly more frequently reported by female patients.
No significant difference in symptom frequency was found among the virologically confirmed cases, comparing primary and secondary cases or infections due to different serotypes.
The data for serologically confirmed cases suggest that in Puerto Rico the manifestations of dengue fever are, as with dengue hemorrhagic fever in Asia, more prominent among those who are experiencing secondary infections, and this effect may be more marked in the younger age groups.
Mots-clés Pascal : Dengue hémorragique, Dengue, Arbovirose, Virose, Infection, Epidémiologie, Réponse immune, Homme, Sérotype, Virus dengue, Flavivirus, Flaviviridae, Virus, Porto Rico, Antilles, Amérique Centrale, Amérique, Surveillance, Symptomatologie, Age, Sexe, Fièvre hémorragique
Mots-clés Pascal anglais : Dengue hemorrhagic fever, Dengue, Arbovirus disease, Viral disease, Infection, Epidemiology, Immune response, Human, Serotype, Dengue virus, Flavivirus, Flaviviridae, Virus, Puerto Rico, West Indies, Central America, America, Surveillance, Symptomatology, Age, Sex, Hemorrhagic fever
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0021945
Code Inist : 002B05C02I1A. Création : 01/03/1996.