The possibility that low concentrations of serum bilirubin may be associated with increased risk of ischemic heart disease has been examined in a prospective study of 7685 middle-aged British men.
During 11.5 years there were 737 major ischemic heart disease (IHD) events.
A U-shaped relationship was observed between serum bilirubin and risk of IHD.
Low bilirubin was associated with several cardiovascular risk factors, in particular smoking, low concentrations of high-density lipoprotein cholesterol, low forced expiratory volume in 1 s, and low serum albumin.
The U-shaped relationship persisted even after adjusting for several risk factors.
Compared with men in the lowest fifth of the distribution (bilirubin<7 mumol/L), those in the middle range (8-9 mumol/L) showed a 30% reduction in relative risk [RR=0.68 (95% confidence intervals 0.51-0.89) ] in IHD, whereas men in the top fifth (>12 mumol/L) showed similar risk to the lowest fifth [RR=0.99 (95% confidence intervals 0.73-1.34) ], which persisted after exclusion of men with bilirubin>17 mumol/L. The significance of this U-shaped relationship is unclear, but it could be interpreted as support for the role of endogenous antioxidants in the etiology of IHD.
Mots-clés Pascal : Homme, Bilirubine, Sérum, Analyse quantitative, Royaume Uni, Europe, Etiologie, Ischémie, Liquide biologique, Myocarde, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Human, Bilirubin, Serum, Quantitative analysis, United Kingdom, Europe, Etiology, Ischemia, Biological fluid, Myocardium, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0014726
Code Inist : 002B12A03. Création : 01/03/1996.