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  1. Tuberculosis among urban health care workers : a study using restriction fragment length polymorphism typing.

    Article - En anglais

    Cases of tuberculosis identified during 1992-1994 through an active tuberculosis surveillance network among six hospitals that serve New York City (the TBNetwork) were analyzed according to the occupational status of the patients.

    Clinical data were obtained by review of medical records, and restriction fragment length polymorphism (RFLP) typing of Mycobacterium tuberculosis isolates was performed.

    No known nosocomial outbreaks of tuberculosis occurred at these hospitals in the study period.

    Occupational status was known for 142 of 201 patients whose isolates were available for strain typing.

    Patients infected by organisms with a clustered strain typing pattern, as determined by RFLP analysis, were presumed to have recently acquired disease.

    RFLP typing revealed that isolates from 13 (65%) of 20 health care workers and 50 (41%) of 122 non-health care workers had a clustered RFLP pattern.

    The strains infecting eight (89%) of nine health care workers seropositive for human immunodeficiency virus (HIV) had a clustered RFLP pattern.

    Multivariate analysis of 75 patients with known HIV and occupational status revealed that HIV status (P=03) and health care worker status (P=02 ; RR=2.77) were independent risk factors for a clustered RFLP strain.

    These findings suggest that many of the apparently sporadic cases of tuberculosis among health care workers may be due to unrecognized occupational transmission.

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Zone urbaine, Homme, Exploration microbiologique, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Exposition professionnelle, Polymorphisme longueur fragment restriction, Personnel sanitaire, Surveillance sanitaire, Typage, Hygiène, Médecine travail

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Urban area, Human, Microbiological investigation, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Occupational exposure, Restriction fragment length polymorphism, Health staff, Sanitary surveillance, Typing, Hygiene, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0013930

    Code Inist : 002B05B02O. Création : 01/03/1996.