Using log-linear Poisson modelling, trends in childhood cancer mortality among the population under 20 years of age in Spain are described over the 35-year period from 1956 to 1990.
Overall cancer mortality and seven specific sites were considered : all leukaemias, Hodgkin's disease, non-Hodgkin's lymphomas, malignant brain tumours, kidney cancer, malignant bone neoplasms, and a broad category of ill-defined tumours.
An age-period-cohort model was used to analyse the influence of age, period of death and birth cohort.
Recent trends were estimated by restricting analysis to the last three 5-year periods.
In general, mortality began to decline at the beginning of the 1970s, with reductions of 36% in males and 45% in females being registered between 1966-1970 and 1986-1990.
The use of age-period-cohort models revealed an initially rising period effect attributable to diagnostic advances.
The decline in mortality in post-1965 generations and the final downturn in the period effect are both most certainly a consequence of the remarkable progress achieved in the treatment of such tumours.
During the final 15 years, there was a relative decline in mortality of approximately 20% every 5 years.
However, in the case of malignant renal tumours in males and malignant bone tumours and non-Hodgkin's lymphomas in both sexes the situation remained stable.
Mots-clés Pascal : Tumeur maligne, Enfant, Homme, Adolescent, Mortalité, Espagne, Europe, Epidémiologie
Mots-clés Pascal anglais : Malignant tumor, Child, Human, Adolescent, Mortality, Spain, Europe, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0010810
Code Inist : 002B04B. Création : 01/03/1996.