The future of mechanistic research in risk assessment : where are we going and can we get there from here ?
Biological mechanisms and quantitative risk assessment. Symposium. USA, 1993/11/01.
Quantitative estimates of human health risk are often based on mathematical models fit to experimental or epidemiological data.
Recent years have witnessed a trend towards the use of mechanistic models in risk assessment applications.
Such models afford a more biologically based interpretation of the data and a firmer scientific basis for extrapolation beyond the conditions under which the original data were obtained.
In this article, we review some recent advances in the development of biologically based models for mutagenesis, carcinogenesis and developmental toxicity.
Pharmacokinetic and receptor-binding models and their roles in mechanistic risk assessment are also discussed.
The future of mechanistic research in risk assessment is contemplated, including the need for more elaborate experiments to obtain the data necessary for mechanistic modeling.
Mots-clés Pascal : Analyse risque, Mécanisme action, Toxicologie, Environnement, Recherche scientifique, Analyse quantitative, Perspective, Approche mécaniste
Mots-clés Pascal anglais : Risk analysis, Mechanism of action, Toxicology, Environment, Scientific research, Quantitative analysis, Perspective, Mechanistic approach
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0007518
Code Inist : 002B03A. Création : 01/03/1996.