Biological mechanisms and quantitative risk assessment. Symposium. USA, 1993/11/01.
TOXICOLOGY, vol. 102, n° 1-2, 1995, pages 53-70, réf. 2p., ISSN 0300-483X, IRL
GODDARD (M.J.), KREWSKI (D.), SETZER (Rwoodrow-Jr) / éd., GRAY (Learl-Jr) / éd.
Us environmental protection agency. National health environmental effects res lab. Research Triangle Park NC. USA, Environmental health cent. Ottawa ON. CAN / com.
Quantitative estimates of human health risk are often based on mathematical models fit to experimental or epidemiological data.
Recent years have witnessed a trend towards the use of mechanistic models in risk assessment applications.
Such models afford a more biologically based interpretation of the data and a firmer scientific basis for extrapolation beyond the conditions under which the original data were obtained.
In this article, we review some recent advances in the development of biologically based models for mutagenesis, carcinogenesis and developmental toxicity.
Pharmacokinetic and receptor-binding models and their roles in mechanistic risk assessment are also discussed.
The future of mechanistic research in risk assessment is contemplated, including the need for more elaborate experiments to obtain the data necessary for mechanistic modeling.
Mots-clés BDSP : Mesure risque, Toxicologie, Environnement
Mots-clés Pascal : Analyse risque, Mécanisme action, Toxicologie, Environnement, Recherche scientifique, Analyse quantitative, Perspective, Approche mécaniste
Mots-clés Pascal anglais : Risk analysis, Mechanism of action, Toxicology, Environment, Scientific research, Quantitative analysis, Perspective, Mechanistic approach
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Cote : 96-0007518
Code Inist : 002B03A. Création : 01/03/1996.