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  1. Research to strengthen the scientific basis for health risk assessment : a survey of the context and rationale for mechanistically based methods and models.

    Article, Communication - En anglais

    Biological mechanisms and quantitative risk assessment. Symposium. USA, 1993/11/01.

    Assessment of health risks is an integral part of regulatory decision-making that occurs at the interface between science (e.g. facts) and policy (e.g. values).

    Because existing scientific knowledge and understanding are often inadequate to answer the most critical risk-related questions, regulatory agencies have developed sets of formalized'science policies'to extrapolate from existing data to real-life events and situations.

    These science policies, as, for example, the use of default assumptions or exposure scenarios, can introduce significant uncertainties into the final risk estimate.

    We survey the rationale for research to reduce extrapolation-related uncertainties, focusing specifically on the need to develop mechanistically based methods and models, including test methods to identify and characterize health effects, integrated human exposure models, physiologically based pharmacokinetic (PBPK) models and biologically based dose-response (BBDR) models.

    Mots-clés Pascal : Mécanisme action, Analyse risque, Toxicologie, Prise décision, Aspect politique, Législation, Incertitude, Modèle, Méthode étude, Homme, Recherche scientifique, Modèle PBPK, Approche mécaniste

    Mots-clés Pascal anglais : Mechanism of action, Risk analysis, Toxicology, Decision making, Political aspect, Legislation, Uncertainty, Models, Investigation method, Human, Scientific research, PBPK modeling, Mechanistic approach

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0007515

    Code Inist : 002B03A. Création : 01/03/1996.