Identification of urinary metabolites of human subjects exposed to o-dichlorobenzene.
o-Dichlorobenzene (o-DCB) has adverse effects on the liver and kidney in animals.
It also causes some irritation to the eyes and the upper respiratory system in humans.
This study aimed to identify urinary metabolites of human subjects exposed to o-DCB.
Urine samples were collected from three male workers exposed to o-DCB and were analyzed using a gas chromatograph-mass spectrometer. 2,3-and 3,4-dichlorophenols and 3,4-and 4,5-dichlorocatechols were detected in the all samples.
Some amounts of the four metabolites were presumably present as conjugates, because they increased after heating with hydrochloric acid.
Mots-clés Pascal : Exposition professionnelle, Homme, Surveillance biologique, Urine, Métabolite, Analyse quantitative, Identification, Analyse qualitative, Médecine travail, Métabolisme, Benzène(1,3-dichloro)
Mots-clés Pascal anglais : Occupational exposure, Human, Biological monitoring, Urine, Metabolite, Quantitative analysis, Identification, Qualitative analysis, Occupational medicine, Metabolism
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0007279
Code Inist : 002B03L06. Création : 01/03/1996.