Urinary 1-naphthol and 1-pyrenol as indicators of exposure to coal tar products.
Chemical exposure of assemblers handling creosote-impregnated wood and of a single worker chiselling coal tar pitch layer was assessed by measuring airborne naphthalene and various polycyclic aromatic hydrocarbons (PAHs), and by measurement of urinary excretion of 1-naphthol and 1-pyrenol.
The sum concentration of PAHs and of 4-6 aromatic ring-containing PAHs were high, 440 mug/m3 and 290 mug/m3, respectively, when chiselling.
In the assembler's workplace, the PAH concentrations were about 1/50 of this value.
Regarding airborne naphthalene concentrations the situation was reversed (assemblers, 1000 mug/m3 ; chiseller, 160 mug/m3).
Correspondingly, the assemblers'urinary 1-napthol concentrations were 15-20 times higher than those of the chiseller.
The urinary 1-pyrenol concentration of the chiseller was 2-4 times higher than among the assemblers.
As the estimated pyrene inhalation doses among the assemblers could account for only about 2% - 25% of the 24-h pyrenol excretion in urine, the skin was presumably the main route of uptake.
For an assessment of the exposure to PAHs, air measurements, monitoring of metabolites in urine and preferably also data on the composition of the skin-contaminating product are needed.
Mots-clés Pascal : Goudron houille, Exposition professionnelle, Homme, Surveillance biologique, Marqueur biologique, Urine, Créosote, Chiselage, Assemblage, Médecine travail, Composé aromatique polycyclique, Naphtalène, Teneur air ambiant, Analyse quantitative
Mots-clés Pascal anglais : Coal tar, Occupational exposure, Human, Biological monitoring, Biological marker, Urine, Creosote, Chiseling, Joining, Occupational medicine, Polycyclic aromatic compound, Naphthalene, Ambient air concentration, Quantitative analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0007278
Code Inist : 002B03L06. Création : 01/03/1996.