Very few prospective studies have reported previously on the association of micronutrient intake and the risk of cancers of the upper digestive tract (mouth, pharynx, esophagus, and stomach) in western populations.
During 7 years of follow-up in the Iowa Women's Health Study, from 1986-1992,59 of the 34,691 at-risk cohort members developed cancers of the upper digestive tract.
The association of retinol and antioxidant vitamins (carotene and vitamins C and E) were evaluated separately for cancers of the mouth/pharynx/esophagus (n=33) and stomach (n=26).
After adjustment for age, smoking, and total energy intake, higher intakes of carotene and vitamins C and E were related to lower risks of both oral/pharyngeal/esophageal and gastric cancers, while retinol was associated with lower risk of gastric cancer only.
The dose-response relation between gastric cancer risk and intake of carotene was clear and statistically significant, with relative risks of 0.6 and 0.3, respectively, observed among women in the upper two versus the lowest tertiles of intake.
This study provides further evidence that higher intake of antioxidant vitamins may be important in the prevention of cancers of the upper digestive organs.
Mots-clés Pascal : Tumeur maligne, Oesophage, Voie aérodigestive supérieure, Estomac, Cavité buccale, Homme, Femelle, Postménopause, Rétinol, Vitamine, Antioxydant, Alimentation, Régime alimentaire enrichi, Etude longitudinale, Estomac pathologie, Oesophage pathologie, Cavité buccale pathologie, Appareil digestif pathologie, Stomatologie, Epidémiologie, Iowa, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Malignant tumor, Esophagus, Upper aerodigestive tract, Stomach, Oral cavity, Human, Female, Postmenopause, Retinol, Vitamin, Antioxidant, Feeding, Supplemented diet, Follow up study, Gastric disease, Esophageal disease, Oral cavity disease, Digestive diseases, Stomatology, Epidemiology, Iowa, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006068
Code Inist : 002B13A01. Création : 01/03/1996.