N, N-dimethylbenzylamine : occupational exposure, analysis and biological monitoring.
Dimethylbenzylamine (DMBA) is used in the production of epoxy resins.
The aims of this study were to assess occupational exposure to DMBA and evaluate the usefulness of monitoring the urinary excretion of DMBA and DMBA metabolites as indicators of exposure to DMBA.
A sensitive gas chromatographic method for analysis of DMBA in air and in urine has been developed.
The detection limit for DMBA in air for a 60-1 air sample collected in 10 ml absorption solution was 2 mug/m3 and in charcoal tubes, 0.3 mug/m3.
The detection limit for DMBA in urine was 0.02 mg/l. Ten male workers manufacturing epoxy resin were monitored during a full shift in the working environment and urine samples were collected at the end of exposure.
The mean exposure and the highest DMBA concentration observed in air were 18 mug/m3 (time-weighted average ; range 3-48 mug/m3) and 91 mug/m3, respectively.
The DMBA concentrations in the urine samples were below the detection limit.
After reduction of the urine samples the DMBA concentrations (U-SumDMBA) ranged from 0.02 to 0.22 mg/l. There was significant correlation between the exposure to DMBA and the U-SumDMBA.
This observation suggests that the U-SumDMBA in urine samples collected at the end of a shift is a useful indicator of occupational exposure to DMBA.
Mots-clés Pascal : Epoxyde résine, Exposition professionnelle, Homme, Surveillance biologique, Urine, Teneur air ambiant, Lieu travail, Contrôle, Analyse quantitative, Médecine travail, Industrie, Benzylamine(N,N-diméthyl)
Mots-clés Pascal anglais : Epoxy resin, Occupational exposure, Human, Biological monitoring, Urine, Ambient air concentration, Work place, Check, Quantitative analysis, Occupational medicine, Industry
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0006002
Code Inist : 002B03L06. Création : 01/03/1996.