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  1. HLA-linked susceptibility and resistance genes in Crohn's disease.

    Article - En anglais

    Background & Aims 

    Previous studies have shown a positive association of HLA-DR4-DQ4 with Crohn's disease in the Japanese population, but the association between Crohn's disease and HLA genes has yet to be fully elucidated.

    The aim of this study was to determine the Crohn's disease/HLA association using a DNA typing method.

    Methods 

    A total of 90 unrelated patients with Crohn's disease and 336 healthy controls were typed for HLA class II genes including DP using DNA typing with the polymerase chain reaction-sequence-specific oligonucleotide probes method.

    Results 

    Allelic analysis showed that DRB1*0405, DRB1*0410, DQA1*03, DQB1*0401, and DQB1*0402 are positively associated and DRB1*1501, DRB1*1302, and DQB1*0602 negatively associated with Crohn's disease.

    DP genes showed no significant association with Crohn's disease.

    Haplotype analysis showed positive associations with DRB1*0405 - DQA1*03 - DQB1*0401, DRB1*0410-DQA1*03-DQB1*0402, and DRB1*0802-DQA1*03-DQB1*0402 haplotypes and negative associations with DRB1*1501-DQA1*0102-DQB1*0602 and DRB1*1302-DQA1*0102-DQB1*0604 haplotypes.

    Conclusions 

    In Crohn's disease in the Japanese population, the HLA-linked disease susceptibility gene is primarily associated with DQB1*04, in which leucine at the 56th position is a unique amino acid, and the disease resistance allele is suggested to be DQA1*0102.

    Mots-clés Pascal : Entérite Crohn, Facteur risque, Système HLA-DR, Prévalence, Résistance, Epidémiologie, Exploration immunologique, Homme, Japon, Asie, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire

    Mots-clés Pascal anglais : Crohn disease, Risk factor, HLA-DR-System, Prevalence, Resistance, Epidemiology, Immunological investigation, Human, Japan, Asia, Digestive diseases, Intestinal disease, Inflammatory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0003199

    Code Inist : 002B13B03. Création : 01/03/1996.