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  1. Screening for neuroblastoma : a 9-year birth cohort-based study in Niigata, Japan.

    Article - En anglais

    Between April 1985 and March 1994 (9 years), 229 346 babies were born in Niigata prefecture, and 201 888 (88.0%) underwent mass screening (MS) for neuroblastoma at 6 months of age.

    To date, 29 infants have been screen-detected as having neuroblastoma (1 : 7908).

    All screen-detected patients survived after removal of the primary tumor.

    In the same birth cohort, 17 additional children were clinically diagnosed as having neuroblastoma.

    The cumulative incidence rate of neuroblastoma at 5 years of age was 10.5 per 100 000 live births in the 5-year birth cohort before MS was introduced, and 18.6 per 100000 in the first 5-year birth cohort after MS was introduced.

    These values were not statistically different.

    The birth cohort incidence rate increased significantly to 22.2 per 100000 (p<5% compared with before MS) after the method of MS was changed to high-power liquid chromatography (HPLC), even though this latest birth cohort has not been followed for 5 years.

    The population-based mortality rate from neuroblastoma was 5.9 per 100000 in the 5-year birth cohort before MS, and 4.5 per 100 000 after MS in the first 5-year birth cohort, using the vanillymandelic acid (VMA) spot test.

    These values were not statistically significant.

    In contrast, no death was observed in the next 4-year birth cohort after MS using HPLC ; however, this birth chohort has not yet been followed for 5 years.

    Mots-clés Pascal : Système nerveux pathologie, Dépistage, Enfant, Homme, Neuroblastome, Tumeur maligne, Système nerveux sympathique pathologie, Japon, Asie, Etude cohorte

    Mots-clés Pascal anglais : Nervous system diseases, Medical screening, Child, Human, Neuroblastoma, Malignant tumor, Autonomic neuropathy, Japan, Asia, Cohort study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0000622

    Code Inist : 002B17E. Création : 01/03/1996.