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  1. Acceptability of HIV vaccine trials in high-risk heterosexual cohorts in Mombasa, Kenya.

    Article - En anglais

    Objectives 

    To ascertain the level of acceptance of a prophylactic HIV vaccine trial in high-risk HIV-seronegative heterosexual cohorts of men and women in Mombasa, Kenya, and to assess the anticipated effects of participation on risk behavior.

    Methods 

    Standardized questionnaire administered to a convenience sample of commercial sex workers and trucking company employees enrolled in prospective cohort studies.

    Results 

    Ninety-six per cent of respondents believed that HIV was a major problem in Kenya and 86% of men and 94% of women perceived themselves at risk.

    One hundred per cent of women and 84% of men expressed interest in participation in an HIV vaccine trial, after explanation of the experimental nature of the vaccine, double-blind placebo-controlled design, prolonged follow-up and potential change in serostatus.

    Seventeen per cent of men and 9% of women anticipated an increase in risk behavior as a result of participation.

    Conclusion 

    The majority of individuals in two high-risk cohorts were interested in participating in Phase III efficacy trials of HIV vaccines.

    A significant minority anticipated an increase in risk behavior, which emphasizes the need for intensive counseling and education throughout a vaccine trial.

    Mots-clés Pascal : SIDA, Virose, Infection, Hétérosexualité, Acceptation, Homme, Essai clinique, Immunoprophylaxie, Vaccin, Facteur risque, Kenya, Afrique, Immunopathologie, Immunodéficit, Prévention

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Heterosexuality, Acceptance, Human, Clinical trial, Immunoprophylaxis, Vaccine, Risk factor, Kenya, Africa, Immunopathology, Immune deficiency, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0589210

    Code Inist : 002B06D01. Création : 01/03/1996.