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  1. The B7 cross reactive group and spondyloarthropathies : an epidemiological approach.

    Article - En anglais

    Objective

    To study the association between the B7 cross reactive group (B7, B40) and spondyloarthropathy (SpA), taking into account patients with atypical features.

    Methods

    We studied the main clinical and paraclinical features of 51 patients with rheumatoid arthritis, 55 with SpA, 120 with mechanical diseases, and 160 with inflammatory rheumatism not fulfilling the diagnostic criteria currently used.

    This descriptive analysis was performed using multiple correspondence factorial analysis to identify subgroups among unclassified patients and select SpA variants.

    We compared HLA frequencies among these groups versus a control group.

    Results

    We identified a subgroup close to the axial SpA and related to B7 (OR : 5.91, p=0.0008), whereas B40 is related to patients close to the peripheral SpA.

    Conclusion

    B7 is related to axial SpA variants manifested by inflammatory low back pain according to Calin's criteria, with either extraarticular signs or sacroiliitis.

    Followup of such patients is equired to determine whether their disease is a new entity or can be considered SpA.

    Mots-clés Pascal : Rhumatisme inflammatoire, Homme, Epidémiologie, Forme clinique, Symptomatologie, Système HLA, Locus HLA-B, Phénotype, Système ostéoarticulaire pathologie, Spondylarthropathie

    Mots-clés Pascal anglais : Inflammatory joint disease, Human, Epidemiology, Clinical form, Symptomatology, HLA-System, HLA-B-Locus, Phenotype, Diseases of the osteoarticular system, Spondylarthropathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0576858

    Code Inist : 002B15D. Création : 01/03/1996.