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  1. Potential impact of genetic testing on cancer prevention trials, using breast cancer as an example.

    Article - En anglais

    Using breast cancer as an example, we explored the potential impact that a highly predictive genetic test could have on the design and analysis of cancer prevention trials.

    We discuss three situations in this article : 1) trials that are in progress when the genetic test first becomes available as a research tool but is not available for general use, 2) trials in progress when the genetic test becomes generally available to the public, and 3) trials that begin after the test becomes generally available.

    We have concluded that the availability of a highly predictive genetic test will provide impediments to prevention trials in the form of increased noncompliance and also will provide opportunities in the form of new trials that include only persons at very high risk of developing cancer.

    Such trial designs could, under favorable circumstances, substantially reduce the size, duration, and cost of cancer prevention trials.

    The availability of a highly predictive genetic test will make the discovery of effective interventions even more urgent, and the randomized trial will still provide the most reliable method of evaluating prevention strategies. [J Natl Cancer Inst 87 : 1137-1144,1995].

    Mots-clés Pascal : Tumeur maligne, Génétique, Prévention, Etats Unis, Amérique du Nord, Amérique, Homme

    Mots-clés Pascal anglais : Malignant tumor, Genetics, Prevention, United States, North America, America, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0555627

    Code Inist : 002B04C. Création : 01/03/1996.