This study sought to estimate the risk of silicosis by cumulative exposure-years in a cohort of miners exposed to silica, as well as the lifetime risk of silicosis under the current Occupational Safety and Health Administration (OSHA) standard (0.09 mg/m3).
In a cohort study of 3330 gold miners who worked at least 1 year underground from 1940 to 1965 (average 9 years) and were exposed to a median silica level of 0.05 mg/m3 (0.15 mg/m3 for those hired before 1930), 170 cases of silicosis were determined from either death certificates or two cross-sectional radiographic surveys.
The risk of silicosis was less than 1% with a cumulative exposure under 0.5 mg/m3-years, increasing to 68% to 84% for the highest cumulative exposure category of more than 4 mg/m3-years.
Cumulative exposure was the best predictor of disease, followed by duration of exposure and average exposure.
After adjustment for competing risks of death, a 45-year exposure under the current OSHA standard would lead to a lifetime risk of silicosis of 35% to 47%. Conclusions.
Almost 2 million US workers are currently exposed to silica.
Our results add to a small but increasing body of literature that suggests that the current OSHA silica exposure level is unacceptably high. (Am J Public Health. 1995 ; 85 : 1372-1377).
Mots-clés Pascal : Silicose, Exposition professionnelle, Mine, Minerai or, Silice, Epidémiologie, Toxicité, Relation dose réponse, Dose cumulée, Homme, Médecine travail, Etude longitudinale, Dakota du Sud, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Poumon pathologie, Pneumoconiose, Maladie professionnelle
Mots-clés Pascal anglais : Silicosis, Occupational exposure, Mine, Gold ore, Silica, Epidemiology, Toxicity, Dose activity relation, Cumulated dose, Human, Occupational medicine, Follow up study, South Dakota, United States, North America, America, Respiratory disease, Lung disease, Pneumoconiosis, Occupational disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0554317
Code Inist : 002B03L03. Création : 01/03/1996.